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Coles R, Kushnir MM, Nelson GJ, McMillin GA, Urry FM

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In addition, the suppression of STAT-6 serine phosphorylation by inhibitors of p38 and MEK1/2 blocked the p300/Stat-6 interaction and suppressed IL-4/IL-13-induced expression of inflammatory chemokines such as CXCL1, CXCL3, CCL2, and CCL11 (eotaxin-1)

Prophylactic administration (before mycotoxin exposure) is generally more effective than therapeutic administration (after exposure), particularly for binding-based mechanisms that prevent initial toxin absorption (100)